In vitro study | Sedoheptulose 7-phosphate can be converted to ADP-l-glycero-β-d-manno-heptose by SepB, SepL, and SepC, it involves in ADP-sugar in microbial natural product biosynthesis.SepB is an S-7-P isomerase, SepL involves in the biosynthesis of heptoses of the core region of E. coli LPS, and they catalyze a four-reaction relay converting S-7-P into ADP-d- glycero -β-d-manno-heptose .Septacidin and its analogs are potential anticancer and pain-relief agents.Hygromycin B is an anthelmintic agent practically used in swine and poultry farming. |